Linezolid: low pre-treatment platelet values could increase the risk of thrombocytopenia.
نویسندگان
چکیده
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منابع مشابه
Efficacy of linezolid on gram-positive bacterial infection in elderly patients and the risk factors associated with thrombocytopenia
UNLABELLED Objective : Linezolid is active against drug-resistant gram-positive bacteria. However, the efficacy and safety of linezolid in the treatment of the elderly have not been well characterized. The purpose of this study was to evaluate the efficacy of linezolid in the treatment of the elderly with gram-positive bacterial infection and to investigate the risk factors associated with the ...
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Thrombocytopenia is a common side effect of linezolid, an oxazolidinone antibiotic often used to treat multidrug-resistant Gram-positive bacterial infections. Various risk factors have been suggested, including linezolid dose and duration of therapy, baseline platelet counts, and renal dysfunction; still, the mechanisms behind this potentially treatment-limiting toxicity are largely unknown. A ...
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OBJECTIVES The primary objectives were to compare the incidences of severe thrombocytopenia, critical thrombocytopenia and a relative decline in platelets from baseline (≥50% decline) between patients receiving linezolid and those receiving vancomycin. The secondary objective was to assess the relationship between vancomycin trough concentration and adverse platelet outcomes. METHODS A matche...
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The most frequently encountered adverse effects of linezolid therapy are anemia and thrombocytopenia, both of which are observed mostly in individuals receiving the drug for 12 weeks, and both of which are generally reversible after discontinuation of treatment. This effect appears to be the result of bone marrow suppression, possibly as a consequence of inhibition of mitochondrial protein synt...
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عنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 56 2 شماره
صفحات -
تاریخ انتشار 2005